Stemolecule™ PD0325901（MEK抑制劑）

產品關鍵詞：

MEK；na?ve stem cells 初始干細胞；neural progenitor cells 神經祖細胞；WH-4-023；CHIR99021；CAS：391210-10-9；

產品描述：

PD0325901是一種靶向MAPK（MAPK/ERK kinase 或MEK）的小分子，具潛在的抗腫瘤活性。PD0325901是MEK抑制劑CI-1040的衍生物，選擇性結合和抑制MEK，可能引起MAPK/ERK的磷酸化和活化，抑制腫瘤細胞增殖。與ALK5抑制劑SB431542一起，PD0325901能夠提高人原代成纖維細胞重編程為誘導多潛能干細胞（iPS）的能力。

Stemgent公司提供支持初始潛能干細胞應用需要的5i/L/A培養基添加劑（5i/L/A media supplment）所有成分，如下：

產品特性

1. 同義名：N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

2. 分子式：C₁₆H₁₄F₃IN₂O₄

3. 分子量：482.19 g/mol

4. CAS NO: 391210-10-9

5. 純度：＞97%（HPLC）

6. 外觀：Pale purple solid

7. 溶解性：DMSO

8. 保存和穩定性：粉末4 °C避光保存，重溶后的儲存液分裝后-20 °C保存，6個月穩定。

9. 質量控制：HPLC測定純度，MS測定準確分子量，PD0325901對小鼠胚胎干細胞的細胞毒性測試。

10. 結構圖：

訂購信息：原裝好貨，歡迎訂購，：，：。

引用文獻：

• Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. "Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules." Stem Cells International 2016:4304916 (2016)

• Liu G. "No detection of potential cancer risk for free-viral reprogrammed stem cell-derived dopaminergic neurons from adult mice fibroblasts." J Stem Cell Res Ther 5:286 (2015)

• Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)

• DeRosa BA; Belle KC; Thomas BJ; Cukier HN; Pericak-Vance MA; Vance JM; Dykxhoom DM. "hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells." Mol Cell Neurosci 68:244 (2015)

• Ying, Q., Tai, C. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. Journal of Cell Science 126, 1093 – 1098.(2013)

• Moraveji S-F; Attari F; Shahverdi A; Sepehri H; Farrokhi A; Hassani S; Fonoudi H; Aghdami N; Baharvand H. "Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis." Human Reproduction 27:2312 (2012)

• Chiang P-M; Wong PC. "Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: Essential role of bone morphogenetic protein 4." Development 138: 2833-2843 (2011)

• Nagy, K., Sung, H-K., Zhang, P., Laflamme, S., Vincent, P, Agha-Mohammadi, S., Woltjen, K., Monetti, C., Michael, I. P., Smith, L. C., Nagy, A. Induced Pluripotent Stem Cell Lines Derive from Equine Fibroblasts. Stem Cell Reviews and Reports 7:693 (2011).

• Wang, B., Miyagoe-Suzuki, Y., Yada, E., Ito, N., Nishiyama, T., Nakamura, M., Ono, Y., Motohashi, N., Segawa, M., Masuda, S., Takeda, S. Reprogramming Efficiency and Quality of Induced Pluripotent Stem Cells (iPSCs) Generated from Muscle-derived Fibroblasts of MDX Mice at Different Ages. PLOS Currents Muscular Dystrophy. 2011 Oct 27 . Edition 1. doi: 10.1371/currents.RRN1274 .

• Mack, A., Kroboth, S., Rajesh, D., Wang, W. B. Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-Integrating Episomal Vectors. PLoS One; 6(11): e27956.(2011)

• Li, W., Zhou, H., Abujarour, R., Zhu, S., Young Joo, J., Lin, T., Hao, E., Sch?ler, H.R., Hayek, A., Ding, S. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27: 2992-3000.

• Ying, Q.L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., and Smith, A. (2008) The ground state of embryonic stem cell self renewal. Nature 453: 519-523.

— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】

上海懋康生物科技有限公司是一家涉足于生命科學和生物技術領域研究的試劑、儀器和實驗室消耗品與實驗服務工作，主要從事細胞生物學、植物學、分子生物學、免疫學、生物化學、蛋白組學。生物制藥與診斷試劑研發生產等領域。 本公司秉承“以人為本，以誠為信、合同守信"的經營理念。堅持"品質保障"的原則為廣大客戶提供優質產品。

Stemolecule™ PD0325901（MEK抑制劑）

Stemolecule™ PD0325901（MEK抑制劑）

Stemolecule™ PD0325901（MEK抑制劑）